What medication can be given in the instance of Risperidone induced gynecomastia?

• A. Quetiapine
• B. Aripiprazole
• C. Olanzapine
• D. Clozapine

Answer: (B)

Aripiprazole is known to be an effective choice for managing risperidone-induced gynecomastia. This condition often arises due to the elevated prolactin levels associated with risperidone use, as it is a potent antagonist at dopamine D2 receptors which can lead to increased prolactin secretion.

Aripiprazole, on the other hand, acts as a partial agonist at the D2 receptors, which can help to normalize prolactin levels without significantly affecting the dopaminergic system. This means that it can mitigate prolactin-induced side effects such as gynecomastia while also being effective in treating psychiatric symptoms.

Other medications listed, such as quetiapine, olanzapine, and clozapine, do not specifically target the prolactin-related side effects associated with risperidone. While these alternatives may be effective antipsychotics for various conditions, they do not provide the same mechanism of action that directly addresses the elevated prolactin levels. Therefore, aripiprazole stands out as the most suitable option for managing this particular side effect.