Which SSRI is contraindicated in pregnancy?

• A. Citalopram
• B. Fluoxetine
• C. Paroxetine
• D. Escitalopram

Answer: (C)

Paroxetine is identified as contraindicated in pregnancy due to its association with various adverse outcomes. Research indicates that exposure to paroxetine during the first trimester can lead to potential risks such as cardiac defects and other malformations in the developing fetus. This has led to recommendations against its use in pregnant individuals unless the benefits outweigh the risks and no other suitable options are available.

Other SSRIs such as citalopram, fluoxetine, and escitalopram have been studied, and while they may have cautionary recommendations, they do not carry the same level of concern regarding teratogenic effects as paroxetine. As a result, healthcare providers typically consider these alternatives safer for use during pregnancy compared to paroxetine, which significantly influences the clinical decision-making process regarding antidepressant treatment in pregnant patients.